Imaging Molecular Signatures in Oligodendroglioma: Fig. 1.

Imaging molecular signatures in oligodendroglioma.

In this issue of Clinical Cancer Research, Walker et al. (1) report a comprehensive analysis of metabolic rate, tumor grade, contrast enhancement, and molecular genetic alterations in oligodendrogliomas and oligoastrocytomas. Brain tumor metabolism was assessed by single-photon emission computed tomography (SPECT) using two radiolabeled tracers, thallium (Tl) and [F]fluorodeoxyglucose (FDG). Tl...

The Biology Behind Imaging Molecular Signatures in Oligodendroglioma

In this issue of Clinical Cancer Research, Walker et al. (1) report a comprehensive analysis of metabolic rate, tumor grade, contrast enhancement, and molecular genetic alterations in oligodendrogliomas and oligoastrocytomas. Brain tumor metabolism was assessed by single-photon emission computed tomography (SPECT) using two radiolabeled tracers, thallium (Tl) and [F]fluorodeoxyglucose (FDG). Tl...

Imaging correlates of molecular signatures in oligodendrogliomas.

Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and 19q, an early molecular event and favorable prognostic marker in oligodendrogliomas, were reflected in their appearance on magnetic resonance ...

The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma.

BACKGROUND Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally. METHODS In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion ...

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